In 1961, the ideas of the fashionable Western science, cybernetics, went through the walls of KhADI. The institute's leadership conceived the creation of the Department of Automation. The first head appointed was Viktor Pavlovich Lomakin, who had just defended his candidate dissertation on modeling the dynamics of electromechanical systems of excavators. These studies were highly relevant and were carried out on the order of the Novokramatorsk Mechanical Plant.  

A laboratory with several stands for automation devices was allocated to the new department. The production of analog modeling installations for the computer technology laboratory began.  

A graduate program was established at the department, and research was conducted not only in laboratory conditions.

Extensive research was conducted on the dynamics of control processes involving human participation. Systems for protecting the boom from bucket impacts on dragline excavators were invented and manufactured for NKMZ and UZTM.

Digital computers (transistor-based!) "Promin" and later "Nairi-2" appeared in the department's laboratories.

The department was renamed the Department of Automation and Computer Technology (DACT). It gained authority throughout the country. Department staff regularly participated in All-Union and international conferences, symposiums of machine dynamics, modeling, automated electric drives, and control theory.  

The first postgraduate students of the department defended their theses: V.Ya. Krakovsky, I.S. Levitan, A.I. Yudina, O.V. Makarov, M.I. Bogdanov. O.V. Fesenko started research on machine reliability.  

In 1970, V.P. Lomakin defended his doctoral dissertation at MIPT. The scientific direction opened by him prompted the emergence of new works in universities and research institutes working on statistical dynamics and automatic control of machines.

At the IV All-Union Conference on Control Issues in Moscow, N.I. Bogdanov discussed the prospects for creating earth-moving robots in his report for the first time. He was elected to the council for coordinating robotics work. Dissertations by I.Ya. Faustov and A.A. Sohan were defended.  

In 1972, O.V. Makarov became the head of the department. Former contractual works practically ended, and the topics continued only with UZTM. The university administration decided to separate the computing center from the Department of Automation and make it institute-wide (at that time equipped with two computers "Nairi-2").  

Five years later, a competition was announced for the position of the head of the Department of Automation. Doctor of Technical Sciences V.Ye. Tyrsa from KNURE was chosen for the position. At the same time, Associate Professor K.I. Bogatyrenko came to the position from KPI.

Contract research began, including defense-related topics. In a short time, a strong team was formed at the Nisa Department. A. A. Akimov, O. V. Denisenko, O. O. Bitny, A. V. Gorushkin, A. D. Gorbunov, V. I. Gnatyuk, V. V. Dyunyashev, A. D. Zenya, N. V. Skyba, A.I. Kvasha, and others joined the department. The teaching staff was supplemented by O. V. Denysenko, O. I. Gnatyuk, and V. S. Shyrokov.

During its peak in the 1980s, when scientific developments were in demand by actively operating enterprises, 5 doctors and 15 candidates of sciences were trained.  

Among the department's staff, doctoral dissertations were defended by A. F. Sushko, A. V. Panishev, S. A. Kantsedal, O. P. Alekseev, K. I. Bogatyrenko.  

Candidates' dissertations were defended by V. V. Dyunyashev, O. V. Denisenko, V. I. Gnatyuk, A. D. Zenya, L. M. Simbirska, A.I. Levterov, V. V. Zakhodyachenko, A. I. Kvasha, N. V. Skyba, M. M. Kuzmenko, L. D. Zelenska, and others.  

In 1992, the department split into the Department of Automation and the Department of Informatics. The Department of Automation remained in the Mechanical Faculty, while the Department of Informatics became part of the Faculty of Management and Business. From 1992 to 2001, Professor Panishev A. V. headed the Department of Informatics.  

In 1994, the department "changed its registration" and moved to Saltivka in the spacious building of the Faculty of Management and Business. Professors A. V. Panishev and S. O. Kantsedal led the scientific directions of the department. Under their leadership, the following lecturers defended their candidate dissertations: L. P. Burtseva, M. V. Kostikova, L. M. Polozova, O. A. Podolyak.  

In 2001, the department was headed by Levterov A.I. In 2005, the Department of Informatics became part of the Faculty of Mechatronics of Transport Vehicles.  

In 2007, the Department of Informatics organized the All-Ukrainian Scientific and Methodological Conference "Issues of Using Information Technologies in the Educational Process of Technical Universities at the Stage of Implementing the Principles of the Bologna Declaration" at KhNADU.  

In 2010, the department was headed by Nikonov O.Ya., Doctor of Technical Sciences, Professor, Laureate of the President of Ukraine Prize.  

In 2013, the Department of Informatics was merged with the Department of Mechatronics of Automotive Vehicles. The new department was named the Department of Information Technologies and Mechatronics. In 2016, the department was divided into the Department of Computer Technologies and Mechatronics and the Department of Informatics and Applied Mathematics. The Department of Computer Technologies and Mechatronics became part of the Mechanical Faculty, and since then, the department has been headed by Doctor of Technical Sciences, Professor Klets D. M.  

In 2018, the department was headed by Nikonov O.Ya., Doctor of Technical Sciences, Professor, Laureate of the President of Ukraine Prize.  

From 2023 till now, the department is headed by Babenko V.O., Doctor of Economic Sciences, Candidate of Techinical Sciences, Professor.